New mPEG-coated Nanoparticles Clear Slowly from Blood Circulation

New mPEG-coated Nanoparticles Clear Slowly from Blood Circulation

At the April 2017 Annual Meeting of the American Association for Cancer Research, we first reported our long-circulating mPEG-coated PrecisionMRX® superparamagnetic nanoparticles. Since then, we’ve refined the formulation, added manufacturing capacity, and continued to study the capabilities of these remarkable nanoparticles. In a more recent preclinical study, reported earlier in September at the 2017 World Medical Imaging Congress, PK data showed that after 24 hours in circulation, only 10% of injected particles are immobilized in liver and therefore yielding non-specific signal (see chart). This is good news for clinical researchers and other life scientists performing in vivo and in vitro applications such as magnetic particle imaging, ultrasound imaging, hyperthermia, immunoassays, and cell enrichment assays.

Designed for stability in complex media, the new nanoparticles are composed of a 25 nm iron oxide core, coated with a monolayer of oleic acid, a monolayer of amphiphilic polymer, and a monolayer of methoxypolyethylene glycol. mPEG-coated PrecisionMRX nanoparticles are now available in 5 and 10 mg vials. Get 15% off when you order before October 31 — enter coupon code “INTRO” when you check out.

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